In his story, the director paints a vision of the city of Los Angeles, where innocence is mixed with corruption, love with loneliness, and beauty with moral corruption. He takes the viewer on a journey through a mysterious labyrinth of sensations, to a place where dreams and terrifying nightmares meet.

The movie opens with a scene in which a young woman loses her memory in a car accident on Mulholland Drive. Semi-conscious, she finds refuge in a luxurious apartment, into which the aspiring actress moves in the next day. The girls become friends. It turns out that the wounded’s bag is filled with money. The heroines try to unravel the mystery. However, they come across new questions and secrets: empty apartments, strangers, murders and strange night performances.